Angelica de Almeida Lupatelli
State University of Campinas, Brazil
Abstract Title: Formulation of a new functional bio-ink enriched with Rosmarinus officinalis for the personalized treatment of skin lesions
Biography: Angelica Lupatelli is a PhD candidate in Clinical Medicine at the State University of Campinas (UNICAMP) and holds a Master’s degree in Biomedical Engineering. She is a physical therapist and pharmacist, with a focus on translational research, tissue rehabilitation, and health innovation. She works as a professor in hospital and clinical settings, with experience in teaching, research, and evidence-based clinical practice. Her work involves the development and application of protocols aimed at tissue regeneration and innovative therapeutic strategies. She has published scientific articles in national and international journals and has experience in academic advising. She is the founder of the Angelica Lupatelli Institute – Clinic & Academy, integrating science, technology, and evidence-based clinical practice.
Research Interest: Extensive epithelial lesions represent a significant clinical challenge, especially in cases refractory to conventional therapies. The complexity of skin healing, coupled with the lack of widely available effective regenerative treatments, reinforces the need for innovative strategies. The overall objective of this project is to develop a functional and personalized regenerative implant for the treatment of extensive epithelial lesions, based on an innovative bioink composed of hydrogel and mesenchymal stem cells (MSCs), enriched with Rosmarinus officinalis, using 3D bioprinting technology from digital models obtained from medical images. The methodology involves the formulation and optimization of a bioink composed of GelMA-based hydrogel and mesenchymal stem cells (MSCs), which have the potential to differentiate into epithelial cell lines. MSCs also have immunomodulatory properties and secrete trophic factors that promote re-epithelialization. In addition, the bioink will be enriched with bioactive compounds from Rosmarinus officinalis, known for its anti-inflammatory and antioxidant action. Volumetric images of epithelial lesions will be obtained from public medical databases and used to generate customized three-dimensional digital models of the injured areas. The mechanical properties of the bioprinted scaffolds will be evaluated and compared to native epithelial tissue, in addition to in vitro analyses to investigate their biocompatibility and effectiveness in inducing healing. At the end of the study, it is expected to obtain a customized, functional, and biocompatible three-dimensional bioprinted implant with the potential to stimulate epithelial tissue regeneration, contributing to the development of more effective and accessible therapeutic alternatives.